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RESEARCH ARTICLE Open Access Modeling of chemical ...

makethelagphase(λ) and the maximum aggregation rate (v m), which represents the overall aggregation process rate, explicit (Figure 1). This last coefficient more adequately characterizes the reaction rate of fibrillation than the par-ameter conventionally used (k app, defined as specific or ap-parent rate) because it is less sensitive to ...

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US5688651A - Prevention of protein aggregation - Google ...

Aggregated amyloid β-protein (βA4) is a major constituent of the abnormal extracellular amyloid plaque that characterizes the brains of victims of Alzheimer's disease (AD) (Haass and Selkoe, 1993). In vitro studies have shown that some of the metal ions found in biological systems, i.e. Fe, Al and Zn, can accelerate the aggregation process ...

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Cellular pattern formation during Dictyostelium aggregation

We find that the coupled dynamics of cell chemotaxis and cAMP reaction-diffusion lead to the break-up of the initially uniform cell layer and to the formation of the striking cell stream morphology which characterizes the aggregation process in situ.

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Kinetics of Aggregation with Choice - Los Alamos National ...

Kinetics of Aggregation with Choice ... smaller candidate cluster participates in the aggregation process, and nd abundance of moderate clusters at the expense of small and large clusters. Additionally, we investigate aggregation processes ... captured by the scaling function which characterizes the bulk of the density. We also nd an ...

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Dynamics of platelet thrombus formation

shear environment that characterizes thrombus development. In this brief review, we will discuss (i) the clinical evidence ... with stabilization of the aggregation process dependent on the subsequent generation of soluble agonists. Impact of blood flow on platelet aggregation and

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Characterization of platelet aggregation induced by the ...

Tumor cell-platelet interactions have been shown to be involved in the process of metastasis. This study characterizes the aggregation of washed platelets induced by the human uterine ...

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Activating Transcription Factor 5 (ATF5) NIH Public Access ...

facilitates aggregation.11 We suggested that disulfide bond formation minimized solution exposure of this C-terminal region through improved structural retention, resulting in diminished protein aggregation.11 The work presented here further characterizes the contribution of this C-terminal region to the aggregation of ATF5.

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Amyloid diseases: Abnormal protein aggregation in ...

Indeed, abnormal protein aggregation characterizes many, if not all, neurodegenerative disorders, not just AD and Parkinson's disease, but also Creutzfeldt–Jakob disease, motor neuron diseases, the large group of polyglutamine disorders, including Huntington's disease, as well as diseases of peripheral tissue like familial amyloid ...

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Insight into the correlation between lag time and ...

aggregation time constant determining the time scale of the overall aggregation process, and € n≥1 is the aggregation kinetic index pointing how long it takes (in units of θ) for the process to be accomplished after the lag time. Geometrically, n characterizes the steepness of the

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CPS211 Lecture: Class Diagrams in UML - Gordon College

CPS211 Lecture: Class Diagrams in UML Last revised July 24, 2008 ... To introduce aggregation and composition associations 4. To introduce the dependency relationship between classes 5. To review the inheritance relationship between classes, and consider how to use ... In the spirit of "seamless development" that characterizes OO, the

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TIME AGGREGATION OF NORMAL MIXTURE GARCH …

TIME AGGREGATION OF NORMAL MIXTURE GARCH MODELS Carol Alexander and Emese Lazar ISMA Centre, School of Business, The University of Reading ... characterizes financial data. These models are more ... GARCH process, normal mixture, time aggregation 1. Introduction

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Jamming and Tiling inAggregation of Rectangles

The aggregation process uses two-dimensional tiles as its building blocks, and it can and viewed as an idealized self-assembly process [35–38]. This aggregation process conserves area and preserves + FIG. 1: Illustration of the aggregation process (2a). shape as all clusters remain rectangular. Initially the system consists of N identical ...

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(PDF) Thermodynamics of Protein Aggregation

Amyloid protein aggregation characterizes many neurodegenerative disorders, including Alzheimer's, Parkinson's, and Creutz- feldt-Jakob disease. Evidence suggests that amyloid aggregates may share ...

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APPLICATION OF FUZZY-INTEGRATION-BASED MULTIPLE ...

APPLICATION OF FUZZY-INTEGRATION-BASED MULTIPLE-INFORMATION AGGREGATION IN AUTOMATIC SPEECH RECOGNITION ... aggregation process provides for flexibility in using a different computing strategy for each information ... pronunciation variation that characterizes spontaneous speech. The partial syllable-proximity scores have

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Experimental characterization and population balance ...

Experimental characterization and population balance modelling of the dense silica suspensions aggregation process. ... In the case of our aggregation process, one of the main difficulties for modelling is the choice of the aggregation and breakage kernels. ... (u + v)), which characterizes the orthokinetic collisions between particles in a ...

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What is Platelet Aggregation? (with pictures)

 · Platelet aggregation is a crucial step in the process of clot formation, which stops bleeding. A platelet aggregation test can be performed to determine how well platelets are sticking together. The test measures this by using a platelet antagonist to …

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Fundamentals of the Backoff Process in 802.11: Dichotomy ...

Fundamentals of the Backoff Process in 802.11: ... While the aggregation on normal time-scales leads to a Poiss on process, it is approximated by a new limiting process possess- ... and Theorem 2), characterizes the backoff distribution in a tractable and simplistic way, owing to …

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Biophysical characterization screening of biotherapeutics

Biotherapeutics Development of efficacious and robust biologics is a complex process. Light scattering technologies assist at each stage with uniquely versatile technologies for biophysical screening and characterization, from target and candidate discovery to selection, optimization, purification, formulation and manufacturing scale-up.

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ARGEN: The Aggregation Rate GENerator that Monitors ...

AR is the derivative of the Mw(t)/Mo with respect to time during the early, linear phase of aggregation. Equation 1. With solvent and reference value input, ARGEN also characterizes the kinetic change in weight average molecular weight of the sample. By using the early linear regime of Mw(t)/Mo, ARGEN's AR values show good reproducibility.

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Toolkit on the Aggregation of Water Supply and Sanitation ...

The aggregation typology | The design of a successful aggregation should consider both the intended purpose and the context in which it takes place, and characterizes the design of an aggregation as a function of its scope, scale, process, and governance. The infographic below walks through the four design dimensions of WSS utility aggregation ...

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High Throughput Prediction Approach for Monoclonal ...

This study characterizes the monoclonal antibody (mAb) aggregation process and demonstrates a high throughput prediction approach for determining protein aggregation at high concentrations. In addition, the study reveals the mechanism of the aggregation process.

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ACCURACY ANALYSIS OF DATA AGGREGATION FOR …

for next levels of aggregation for different functions. For example, calculation of average requires the sum and count of underlying layers. D. Quality of Aggregation Functions We focus our study on accuracy as the property that primarily characterizes the quality of aggregation. The accuracy of a particular aggregation function is captured by

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In Vitro Study of α-Synuclein Protofibrils by Cryo-EM ...

aggregation characterizes a considerable number of human diseases, such as Alzheimer's, Parkinson's, and Hunting-ton's diseases, and type II diabetes (4,6,7). Moreover, the ... Cryo-EM was used to monitor the aggregation process and collect protofibril images at various incubation times. All

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Sequential Decision Aggregation with Social Pressure

Sequential Decision Aggregation with Social Pressure Wenjun Mei Francesco Bullo Received: date / Accepted: date Abstract This paper proposes and characterizes a sequential decision aggregation system consisting of agents performing binary sequential hypothesis testing, and a fusion center which collects the individual

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Modeling of chemical inhibition from amyloid protein ...

The process of amyloid proteins aggregation causes several human neuropathologies. In some cases, e.g. fibrillar deposits of insulin, the problems are generated in the processes of production and purification of protein and in the pump devices or injectable preparations for diabetics.

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Group Decision-Making Approach Based on Generalized Grey ...

To further address the interrelationships among all elements involved in the aggregation process, Zhang et al. created an operator called dual generalized weighted Bonferroni mean (DGWBM) operator. It not only characterizes the interrelationships among any attribute subsets but also takes the weight of the aggregated argument into account.

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Accuracy Analysis of Data Aggregation for Network Monitoring

Accuracy Analysis of Data Aggregation for Network Monitoring . Nikoletta Sofra . Imperial College, UK . Ting He, Petros Zerfos, Bong Jun Ko, Kang-Won Lee ... as bandwidth utilization and link status and process them into more meaningful, aggregate metrics such as average delay and ... primarily characterizes the quality of aggregation. The

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Particle aggregation - Wikipedia

Particle aggregation is normally an irreversible process. Once particle aggregates have formed, they will not easily disrupt. In the course of aggregation, the aggregates will grow in size, and as a consequence they may settle to the bottom of the container, which is referred to as sedimentation.

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An "aggregation of End Products and Enabling Products to ...

An "aggregation of End Products and Enabling Products to achieve a given purpose" best characterizes: Answer: ... The Transition Process is typically the final 'bot...

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Shape-Independent Model (SHIM) Approach for Studying ...

115 The target parameter of interest that most fully characterizes the equilibrium aggregation 116 process is the equilibrium self-association constant, K (or Gibbs free energy change on aggregation).27 117 The magnitude of K can be obtained from the dependence of the observable parameter (i.e.

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